What Is Spravato and How Does It Treat Depression?

A joyful woman exudes confidence after overcoming depression with the help of Spravato.

As a psychiatrist who has treated patients with depression for many years, I am always searching for innovative treatments that bring hope to those who have not found relief with traditional antidepressant medications. One treatment I am excited to offer in my clinic is Spravato (esketamine), a groundbreaking option for people struggling with treatment-resistant depression.

❓ What Is Spravato?

Spravato, also known as esketamine, is a medication delivered through a nasal spray. Unlike traditional antidepressants, Spravato works on the brain’s glutamate system, which plays an important role in mood regulation. Clinical studies have shown that it can reduce symptoms of depression in patients who have not improved with other treatments.

❓ How Do We Use Spravato in Our Clinic?

At our clinic, Spravato is part of a comprehensive approach to depression treatment. We don’t view it as a “one-size-fits-all” solution but as one of many tools we can use to help patients regain quality of life. Every treatment plan is tailored to the individual.

❓ What Happens Before Starting Spravato?

Before beginning treatment, we sit down with patients to discuss:

• Benefits and risks of Spravato.

• Their medical history and current medications to avoid contraindications.

• Possible side effects, which may include dizziness, nausea, or dissociation.

This thorough review ensures safety and helps patients feel confident about their decision.

❓ What Is a Spravato Treatment Session Like?

When patients come in for Spravato treatment:

1. The nasal spray is administered under medical supervision.

2. Patients relax in a quiet and comfortable treatment room.

3. We closely monitor them for about two hours after treatment to ensure safety and comfort before they leave.

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❓ Is Spravato Used Alone or With Other Medications?

Spravato is now approved as a standalone treatment in addition to alongside an oral antidepressant. We work closely with patients to ensure they are on the right combination of medications and dosages to achieve the best possible results.

❓ Who Should Consider Spravato?

Spravato is most appropriate for people who:

• Have tried multiple antidepressants without success.

• Continue to struggle with treatment-resistant depression.

• Are seeking new, evidence-based options under professional care.

I am proud to offer Spravato as part of our treatment options. It represents a hopeful step forward for many people who have felt stuck in their depression journey. If you are struggling with depression that has not improved with traditional treatments, I encourage you to reach out to a qualified mental health provider to explore whether Spravato could be right for you.

We serve Norwood, Dedham, Westwood, Walpole, Mansfield, Sharon, Foxboro and the surrounding towns in the Greater Boston Area